Table 3.
EAE clinical course.
| Clinical Course | Females (0–20 dpi) |
Females (46 dpi) |
Males (0–20 dpi) |
|||
|---|---|---|---|---|---|---|
| Ast-IL-6 KO (n = 15) |
Floxed (n = 20) |
Ast-IL-6 KO (n = 8) |
Floxed (n = 8) |
Ast-IL-6 KO (n = 11) |
Floxed (n = 18) |
|
| Time of peak score | 14.30 ± 0.53 | 14.80 ± 0.49 | 22.5 ± 2.46 * | 15.5 ± 1.92 | 15.18 ± 0.80 | 13.76 ± 0.6 |
| Peak score | 2.80 ± 0.23 | 3.45 ± 0.16 | 3.68 ± 0.50 | 3.18 ± 0.23 | 3.18 ± 0.18 | 3.14 ± 0.12 |
| Cumulative score | 19.40 ± 2.55 | 24.16 ± 1.32 | 88.87 ± 21.84 | 72.18 ± 10.35 | 20.32 ± 1.64 | 22.61 ± 1.34 |
| Grade of Remission | 0.64 ± 0.13 | 0.91 ± 0.11 | 1.00 ± 0.34 | 1.43 ± 0.27 | 0.82 ± 0.26 | 20.32 ± 1.64 |
Results shown are pooled data from Experiments 1–3 separated by sex and genotype. For simplicity, data from 20–22 dpi were grouped and are referred to as 20 dpi. For each animal, we determined time to peak disease, peak-score, cumulative score (sum of all scores from disease onset to Days 20 and 22 combined or 46), and the grade of remission (difference between peak score and outcome). Results are the mean ± SEM. For statistical analysis at 0–20 dpi, a two-way ANOVA for genotype (floxed vs. Ast-IL-6 KO mice) and sex as the main factors was performed. For the females at 46 dpi, a one-way ANOVA for genotype (floxed vs. Ast-IL-6 KO mice) was performed. * p < 0.05 vs. floxed mice.