Figure 6. Model for the nucleolin contribution in the vRNPs export at the crossroads between chromatin organization and nucleocytoplasmic transport.

(A) Influenza viruses gain preferential access to host cell export machinery by targeting chromatin at the sites of Ran regeneration, as proposed by Chase et al.¹³. As a chromatin remodeler and an interaction partner of histone H1, nucleolin should contribute to the chromatin targeting of vRNPs. (B) The interaction between nucleolin (NCL, yellow diamond) and NP (orange diamond) is placed on the center of the graph (thick edge). Proteins interacting with nucleolin or NP and involved in chromatin organization are in blue squares. Proteins interacting with nucleolin or NP and involved in nucleo-cytoplasmic transport are in red squares. NPM1 (B23) and TP53 involved in both processes are in green squares.