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. Author manuscript; available in PMC: 2016 Jul 4.
Published in final edited form as: Physiology (Bethesda). 2012 Dec;27(6):351–361. doi: 10.1152/physiol.00026.2012

FIGURE 4. Energetic coupling model for CFTR gating.

FIGURE 4

The conformational changes in the TMDs and the NBDs are not strictly coupled, but the conformational change in one domain will facilitate the conformational change in the other domain. ATP hydrolysis, according to this model, simply provides a shortcut for the channel to escape from the absorbing state (O1).