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. Author manuscript; available in PMC: 2016 Jul 4.
Published in final edited form as: J Alzheimers Dis. 2016;52(2):731–745. doi: 10.3233/JAD-151124

Figure 2.

Figure 2

(A) Surface Gadolinium chelate BisStearoyl Amine-DTPA-Gd on nanoparticles exhibits enhanced relaxivity compared to a free Gd chelate(GadobenateDimelglumine, Multihance™) at lower field strengths, but the difference erodes at higher field strengths to the point where at 9.4T, the free chelate is more relaxive than the surface presentation. (B) On a particle basis, at 1T a relaxivity of 180,000 mmol−1s−1 is achieved using 25 mole% of the BSA-DTPA-Gd construct. 1.5, 3, 4.7, 7 and 9.4T measurements were made on individual MRI instruments. 1.4T measurement was made on a Bruker minispec mq60 relaxometer. 1T measurements were made on an Aspect M2 permanent magnet MRI instrument.