Table 2. Clinical characteristics of the study cohort.
| At baseline | At follow-up | Relative reduction (%) | P | |
| Sociodemographic characteristics | ||||
| N (men/women) | 60 (29/31) | |||
| Age (years) | 56 (25–78) | |||
| Body composition | ||||
| Body weight (kg) | 95.1 (60.7–125.6) | 90.5 (58.2–120.1) | −4.6 (−8.0–−0.7) | <0.001 |
| BMI (kg/m2) | 31.9 (22.4–44.8) | 30.6 (21.3–43.5) | −4.7 (−8.1–−0.6) | <0.001 |
| BFM (kg) | 34.5 (16.8–63.4) | 31.8 (13.4–59.5) | −6.9 (−27.0–4.6) | <0.001 |
| BFFM (kg) | 58.2 (39.5–84.9) | 55.3 (39.3–81.9) | −3.3 (−9.1–4.2) | <0.001 |
| TBW (kg) | 42.6 (28.9–62.2) | 40.5 (28.8–60.0) | −3.3 (−9.1–4.1) | <0.001 |
| WC (cm) | 107 (78–127) | 103 (76–128) | −4.1 (−9.2–2.2) | <0.001 |
| VFI | 13 (5–24) | 12 (4–21) | −7.1 (−20.0–11.1) | <0.001 |
| Liver markers | ||||
| CAP (dB/m) | 295 (216–400) | 266 (100–353) | −14.0 (−68.6–38.2) | <0.001 |
| FLI | 83 (7–99) | 63 (4–98) | −21.3 (−74.0–0.0) | <0.001 |
| LSM (kPa) | 6.2 (1.5–11.9) | 5.3 (1.5–12.0) | −11.7 (−70.5–43.6) | 0.002 |
| ALT (U/l) | 38 (12–118) | 36 (14–150) | 0 (−73.1–122.2) | >0.05 |
| AST (U/l) | 25 (10–121) | 24 (8–141) | 0 (−80.2–464.0) | >0.05 |
| AP (U/l) | 74 (37–159) | 64 (32–144) | −11.5 (−43.0–24.1) | <0.001 |
| γ-GT (U/l) | 37 (7–335) | 26 (7–113) | −26.7 (−77.3–50.0) | <0.001 |
| PChE (kU/l) | 10.7 (6.6–17.0) | 10.4 (6.7–15.3) | −3.8 (−22.6–19.2) | 0.006 |
| Metabolic markers | ||||
| Glucose (mg/dl) | 89 (63–232) | 84 (60–126) | −7.1 (−50.4–52.4) | <0.001 |
| TG (mg/dl) | 128 (60–419) | 83 (48–183) | −34.1 (−84.0–35.9) | <0.001 |
| TC (mg/dl) | 214 (147–303) | 163 (95–249) | −23.5 (−45.6–10.9) | <0.001 |
| LDL cholesterol (mg/dl) | 142 (78–226) | 96 (45–193) | −25.3 (−53.1–41.0) | <0.001 |
| HDL cholesterol (mg/dl) | 50 (29–110) | 45 (28–77) | −13.0 (−66.4–28.9) | <0.001 |
| Uric acid (mg/dl) | 6.1 (2.9–8.6) | 5.6 (3.1–10.0) | −7.6 (−40.9–43.5) | 0.024 |
| SBP (mm Hg) | 138 (110–175) | 130 (104–184) | −5.6 (−28.6–40.5) | <0.001 |
| DBP (mm Hg) | 92 (74–125) | 87 (72–120) | −4.5 (−34.2–18.8) | 0.001 |
ALT, alanine aminotransferase; AP, alkaline phosphatase; AST, aspartate aminotransferase; BFFM, body fat free mass; BFM, body fat mass; BMI, body mass index; CAP, controlled attenuation parameter; DBP, diastolic blood pressure; FLI, fatty liver index; γ-GT, gamma-glutamyl transferase; HDL, high-density lipoprotein; LDL, low-density lipoprotein; LSM, liver stiffness measurement; N, number; PChE, pseudocholinesterase; SBP, systolic blood pressure; TBW, total body water; TC, total cholesterol; TG, triglycerides; VFI, visceral fat index; WC, waist circumference.
Significant P values are highlighted in bold.