Table 1. Replicated SNPs in the CHRNB3 gene cluster associated with ND-related behaviors.
| dbSNP ID | Sample origin | Sample size | Phenotype | Odds ratio or β-value | Reported P-value | Reference |
|---|---|---|---|---|---|---|
| rs4950 | EA and Australian | 1929 | ND (FTND) | 1.38 | 0.0001 | 30 |
| Ethnically diverse | 1056 | Subjective responses to tobacco (adverse, negative physical, positive) | 4.88 8.13 12.25 | 0.02, 0.004, <0.001 | 31 | |
| Ethnically diverse | 1524 families | Subjective responses to tobacco | NA | 0.043 | 31 | |
| Caucasian, AA and Hispanic | 1051 | Quit attempts | NA | 0.021 | 32 | |
| Caucasian, AA and Hispanic | 295 | ND | 4.62 | 0.007 | 32 | |
| EA | 2062 | ND | 0.78 | 0.00143 | 33 | |
| EA, AA and Asian (meta-analysis) | 22 654 | ND | 0.1343 | 1.08E−05 | 34 | |
| Ashkenazi | 591 | Smoking status | 1.94 | 9.8E−05 | 35 | |
| rs10958726 | EA and Australian | 1929 | ND (FTND) | NA | 1.33E−04 | 19 |
| EA and Australian | 1929 | ND (FTND) | 1.38 | 9.636E−05 | 30 | |
| EA | 1600 | Early subjective response to tobacco (dizziness) | −0.126 | 0.005 | 36 | |
| EA | 2062 | ND | 0.77 | 0.00113 | 33 | |
| EA, AA and Asian (meta-analysis) | 22 654 | ND | 0.1546 | 1.24E−07 | 34 | |
| rs13280604 | Ethnically diverse | 1056 | Subjective responses to tobacco (adverse, negative physical, positive) | 5.00 12.61 | 0.03, 0.001, <0.001 | 31 |
| Ethnically diverse | 1524 families | Subjective responses to tobacco | NA | 0.011 | 31 | |
| Caucasian, AA and Hispanic | 1051 | Quit attempts | NA | 0.024 | 32 | |
| Caucasian, AA and Hispanic | 295 | ND | 4.67 | 0.006 | 32 | |
| EA, AA and Asian (meta-analysis) | 22 654 | ND | 0.1362 | 7.77E−06 | 34 | |
| Korean | 576 | NDSS (drive) | NA | 0.03 | 37 | |
| rs6474413 | EA and Australian | 1929 | ND (FTND) | NA | 9.36E−05 | 19 |
| EA and Australian | 1929 | ND (FTND) | 1.39 | 6.260E−05 | 30 | |
| EA | 1600 | Early subjective response to tobacco (dizziness) | −0.114 | 0.011 | 36 | |
| EA | 2062 | ND | 0.77 | 9.26E−04 | 33 | |
| rs13277254 | EA and Australian | 1929 | ND (FTND) | 1.4 | 4.022E−05 | 30 |
| EA | 1600 | Early subjective response to tobacco (dizziness) | −0.122 | 0.007 | 36 | |
| EA | 2038 | ND (FTND) | 0.79 | 0.004 | 38 | |
| EA | 2062 | ND | 0.76 | 6.25E−04 | 33 | |
| rs6474412 | EA and Australian | 1929 | ND (FTND) | 1.38 | 1.126E−04 | 30 |
| EA | 1600 | Early subjective response to tobacco (dizziness) | −0.111 | 0.014 | 36 | |
| EA | 2062 | ND | 0.78 | 0.00137 | 33 | |
| EA, AA and Asian (meta-analysis) | 22 654 | ND | 0.1548 | 5.34E−07 | 34 | |
| rs4952 | EA and Australian | 1929 | ND (FTND) | NA | 0.0163 | 19 |
| EA and AA | 2772 | ND | NA | 0.00881 | 33 | |
| EA and AA (meta-analysis) | 5092 | ND (FTND) | 0.72 | 0.02 | 39 | |
| rs1955186 | EA and Australian | 1929 | ND (FTND) | 1.38 | 8.252E−05 | 30 |
| EA | 1600 | Early subjective response to tobacco (dizziness) | −0.119 | 0.009 | 36 | |
| EA | 2062 | ND | 0.77 | 7.38E−04 | 33 | |
| rs1955185 | EA and Australian | 1929 | ND (FTND) | 1.38 | 1.010E−04 | 30 |
| EA | 1600 | Early subjective response to tobacco (dizziness) | −0.118 | 0.009 | 36 | |
| EA | 2062 | ND | 0.78 | 0.00117 | 33 | |
| rs13277524 | EA and Australian | 1929 | ND (FTND) | 1.39 | 6.043E−05 | 30 |
| EA | 1600 | Early subjective response to tobacco (dizziness) | −0.121 | 0.007 | 36 | |
| EA | 2062 | ND | 0.77 | 7.78E−04 | 33 | |
| rs4953 | EA and Australian | 1929 | ND (FTND) | NA | 0.0162 | 19 |
| Ethnically diverse | 1056 | Subjective responses to tobacco (adverse) | 4.16 | 0.04 | 31 | |
| rs4954 | Han Chinese | 48 | ND (FTND) | 2.18 | 4.25E−07 | 40 |
| Korean | 576 | NDSS (drive) | NA | 0.02 | 37 |
Abbreviations: AA, African-American; EA, European-American; FTND, Fagerström Test for Nicotine Dependence; NA, not available; ND, nicotine dependence; NDSS, nicotine-dependence syndrome scale; SNP, single nucleotide polymorphism.