Table 2. The effects of ASD traits and anxiety on BOLD responses during reward anticipation.
Peak MNI coordinates |
|||||||
---|---|---|---|---|---|---|---|
Region | Brodmann area | Cluster size (voxels) | x | y | z | Z | P (FWE) |
Interaction: ASD traits x anxiety | |||||||
R middle and superior temporal gyri, R insula | 21/22/13 | 283 | 45 | −16 | −11 | 3.97 | 0.001 |
57 | −37 | −8 | 3.80 | ||||
63 | −16 | −11 | 3.71 | ||||
High<low ASD traits | |||||||
R superior and medial frontal gyri extending bilaterally to the dACC and MCC | 9/24/32 | 936 | −18 | 17 | 37 | 4.88 | <0.001 |
18 | 17 | 49 | 4.72 | ||||
9 | 50 | 37 | 4.58 | ||||
Any anxiety>no anxiety | |||||||
R middle frontal gyrus | 8 | 254 | 39 | 23 | 43 | 4.41 | 0.002 |
21 | 59 | 37 | 3.89 | ||||
42 | 8 | 49 | 3.66 | ||||
R middle temporal gyrus | 21 | 209 | 45 | −16 | −11 | 3.98 | 0.008 |
60 | −16 | −5 | 3.67 | ||||
57 | −37 | −11 | 3.47 | ||||
ASDANX>ASDONLY | |||||||
R middle temporal gyrus | 21 | 257 | 57 | −37 | −8 | 4.56 | <0.001 |
63 | −13 | −2 | 4.31 | ||||
69 | −37 | −2 | 3.90 | ||||
R middle frontal gyrus | 8 | 251 | 42 | 23 | 43 | 4.27 | <0.001 |
42 | 11 | 52 | 3.71 | ||||
42 | 32 | 43 | 3.45 | ||||
L insula, L inferior frontal gyrus | 13/45/47 | 162 | −42 | 17 | −11 | 4.27 | 0.011 |
−36 | 17 | 1 | 3.43 | ||||
−45 | 17 | 7 | 3.36 | ||||
L inferior parietal lobule | 40 | 124 | −57 | −43 | 55 | 3.86 | 0.047 |
−48 | −61 | 52 | 3.33 | ||||
−66 | −37 | 37 | 3.11 | ||||
L superior and middle temporal gyri | 39/22/40 | 246 | −60 | −67 | 7 | 3.71 | 0.001 |
−51 | −82 | 7 | 3.70 | ||||
−51 | −79 | 22 | 3.68 | ||||
R inferior parietal lobule | 40 | 256 | 51 | −52 | 55 | 3.60 | <0.001 |
60 | −34 | 55 | 3.49 | ||||
48 | −34 | 64 | 3.41 | ||||
ASDANX>ANXONLY | |||||||
L insula, L inferior frontal gyrus | 47 | 186 | −42 | 17 | −8 | 4.68 | 0.017 |
−36 | 14 | 4 | 3.65 | ||||
−54 | 20 | 1 | 3.57 | ||||
L and R cuneus and calcarine | 18/17 | 222 | −12 | −82 | 10 | 4.30 | 0.006 |
12 | −85 | 10 | 3.77 | ||||
−6 | −76 | 22 | 3.38 |
Abbreviations: ANXONLY, high anxiety and low ASD traits; ASD, autism spectrum disorder; ASDANX, high ASD traits and anxiety; ASDONLY, high ASD traits, low anxiety; BOLD, blood-oxygen-level dependent; dACC, dorsal anterior cingulate cortex; FWE, family-wise error correction; L, left hemisphere; MCC, middle cingulate cortex; MNI, Montreal Neurological Institute; R, right hemisphere.