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. 2016 Jun 21;6(6):e842. doi: 10.1038/tp.2016.84

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Copyright © 2016 Macmillan Publishers Limited

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(a) Differential effects of imipramine on forced swim test (FST) immobility time between adrenocorticotropic hormone (ACTH)-pretreated- and vehicle animals (n=8–12). Saline-treated animals responded to the antidepressant-like effects following imipramine administration. Treatment resistance induced with a chronic treatment of ACTH for 14 days; (b) ACTH animals show lower capacity to generate ATP in response to the energy demand relative to the vehicle group. State 3 respiration point represents a maximal ADP stimulation respiration. The values are displayed as means and ±s.e.m. *P<0.05, ^†P=0.07.