Table 1. Overview of association between DNA methylation and BD and mQTL for CGI 3 of CACNA1C.

	Methylation difference between BD cases and controls P-value			Focused mQTL analysis			Full mQTL analysis			rs1006737 as mQTL
CpG site	All individuals	Females only	Males only	mQTL (most significant)	P-value	P-value (Bonferroni-corrected 24 markers)	mQTL (most significant)	P-value	P-value (Bonferroni-corrected 2634 markers)	P-value
7	6.16E−07	1.39E−04	9.06E−03	rs2239030	4.36E−05	1.05E−03	rs2239030	4.36E−05	1.15E−01	9.52E−03
26	7.15E−07	1.60E−04	1.23E−02	rs2239030	4.74E−04	1.14E−02	rs4026015	1.49E−05	3.92E−02	2.85E−02
30	2.00E−05	7.20E−03	7.17E−03	rs2238056	2.90E−07	6.96E−06	rs2238056	2.90E−07	7.64E−04	1.36E−04
34	7.70E−01	3.54E−01	7.68E−01	rs2238056	1.38E−04	3.32E−03	rs2238056	1.38E−04	3.65E−01	6.73E−02
35	1.16E−07	1.01E−03	6.41E−04	rs2238056	2.63E−07	6.32E−06	rs2238056	2.63E−07	6.94E−04	3.02E−04
42	8.66E−07	1.54E−04	3.09E−02	rs10848634	2.14E−07	5.13E−06	rs10848634	2.14E−07	5.63E−04	8.47E−05

Abbreviations: BD, bipolar disorder; CGI, CpG island; mQTL, methylation quantitative trait loci.

Entries marked in bold indicate findings with P-value <0.05.