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. 2016 Jun 14;5(2):27. doi: 10.3390/cells5020027

Figure 1.

Figure 1

The Linker of Nucleoskeleton and Cytoskeleton (LINC) complex connects the nucleus to the cytoskeleton. (a) Diagram of a blood vessel (left panel) at two different scales, demonstrating the mechanical continuum that exists between the cell surface adhesion and the nucleus; (b) Schematic representation of the LINC complex. This complex consists in SUN proteins anchored in the inner nuclear membrane (INM) and nesprins anchored in the outer nuclear membrane (ONM). SUN domain was shown to organize in a trimeric fashion to bind three KASH peptides [50,51].