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. 2016 Jul 4;4:13. doi: 10.1186/s40170-016-0153-9

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Enrichment of extracellular metabolites of HPDE and PANC-1 cells on DMEM labelled with [U-¹³C₆]-glucose. Bar graphs show fractional labelling of metabolites measured in triplicates. Alanine enrichment was used as proxy for mitochondrial pyruvate. Acetyl-CoA enrichment was calculated from malate and citrate enrichment. Glucose carbon atoms appear to overflow into lactate, with a small portion entering TCA cycle. Heat map showed a greater dilution of glucose carbons (i.e., loss of ¹³C enrichment) in PANC-1 cells compared to HPDE cells. Asterisk indicates p < 0.05