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. 2016 May 25;3(7):495–511. doi: 10.1002/acn3.318

Figure 4.

Figure 4

Endpoint DTI measures correlate with Basso Mouse Scale (BMS) scores and myelin content. Blue squares are data points for individual mice within the IVIg‐treated group; vehicle‐treated spinal cord injury (SCI) controls are shown as white circles. Trend lines based on regression analysis are shown in black for each graph. (A–C): fractional anisotropy (FA) values in the VF (A), but not LF (B) or the DCs (C), were significantly correlated with BMS scores at 35 days post‐SCI for the cohort. (D) FA values for the combined ventrolateral white matter (VLWM) were trending but nonsignificantly (ns) correlated with myelin content (P = 0.063). (E–G): Endpoint radial diffusivity (RD) values in the VF (E) and the LF (F), but not the DCs (G), tightly correlated with final BMS scores (35 days post‐injury). (H) RD values for the VLWM were also strongly correlated with myelin content at 35 days post‐SCI. Linear regression with Pearson correlation; n = 5–7 per experimental group; *P < 0.05; **P < 0.01; ***P < 0.001. DTI, diffusion tensor imaging.