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Monoclonal Antibodies in the Treatment of Pediatric Asthma
| Name | Therapeutic target | Asthma phenotype/endotype | Approved for use in children |
|---|---|---|---|
| Omalizumab | IgE | Atopic asthma/urban asthma | Yes (≥12 years of age) |
| Mepolizumab | IL-5 | Eosinophilic asthma | Yes (≥12 years of age) |
| Reslizumab | IL-5 | Eosinophilic asthma | Under investigation |
| Lebrikizumab | IL-13 | Elevated periostin | Under investigation |
| Tralokinumab | IL-13 | Eosinophilic asthma | Under investigation |
Abbreviation: IL, interleukin
