Table 1.

Summary of the Roles of Periostin in Bleomycin-Induced Lung Injury From the Three Reports.

	Strain	Intratracheal Administrated Bleomycin (Equivalent Unit, Supplier)	Survival Rate	Cause of Death	Role of Periostin
Uchida et al.6	BALB/c; WT (n=7) vs. KO (n=16)	10 mg/kg (10 U/kg; Nippon Kayaku)	Less than 20% in WT; about 90% in KO (day 28)	Pulmonary fibrosis	Induction of inflammation
Naik et al.8	C57BL/6; periostin-neutralizing antibody (injected 10 and 15 days after bleomycin administration, n=10 each)	0.05 unit per mouse (about 2 U/kg; Sigma)	40% in control antibody; 100% in neutralizing antibody (day 19)	Pulmonary fibrosis	Fibrosis progression
This study	C57BL/6; WT (n=17) vs. KO (n=31)	2.5 U/kg (LKT Laboratories)	About 90% in WT; about 55% in KO (day 21)	Alveolar rupture	Increase in ECM stability

WT and KO indicate the wild-type mice and the periostin-null mice, respectively. Abbreviation: ECM, extracellular matrix.