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. 2016 May 28;8(6):1201–1215. doi: 10.18632/aging.100970

Figure 4. Morphology of white adipose tissue of AdicerKO mice.

Figure 4

Twelve-week old mice were subjected to ad libitum (AL) or dietary restriction (DR) regimens for one (A-C) or three (D) months. Inguinal white adipose tissue (WAT) was isolated and analyzed at the (A,B) ultrastructure level (electron microscopy) or at the (C) histological level (H&E) (N=4-5 animals per condition). L, lipid droplet. M, healthy mitochondrium. m, damaged hypertrophic mitochondrium. Lf, lymph node. N, nucleus. *, fibrosis. (D) Inflammation markers were assessed by RT-qPCR (N=3-4 per condition). Mean ± SEM. ** P < 0.01 for genotype effect; ‡ P < 0.05, ‡‡ P < 0.01 for diet-genotype interaction.