Table 1. Correlation between HDAC4 expressions and clinicopathologic characteristics in ESCC.
| Clinicopathologic characteristics | All cases | HDAC4 mRNA Expression | P value | |
|---|---|---|---|---|
| low | high | |||
| Gender | ||||
| female | 17 | 10 (58.8%) | 7 (41.2%) | 0.417 |
| male | 69 | 33 (47.8%) | 36 (52.2%) | |
| Age (years) | ||||
| < 60 | 44 | 24 (54.5%) | 20 (45.5%) | 0.388 |
| ≥ 60 | 42 | 19 (45.2%) | 23 (54.8%) | |
| Tobacco use | ||||
| no | 32 | 19 (59.4%) | 13 (40.6%) | 0.181 |
| yes | 54 | 24 (44.4%) | 30 (55.6%) | |
| Alcohol use | ||||
| no | 49 | 26 (53.1%) | 23 (46.9%) | 0.514 |
| yes | 37 | 17 (45.9%) | 20 (54.1%) | |
| Tumor location | ||||
| upper and middle | 65 | 35 (53.8%) | 30 (46.2%) | 0.209 |
| lower | 21 | 8 (38.1%) | 13 (61.9%) | |
| Tumor length (cm) | ||||
| < 5 cm | 57 | 29 (50.9%) | 28 (49.1%) | 0.82 |
| ≥ 5 cm | 29 | 14 (48.3%) | 15 (51.7%) | |
| Pathological Grade | ||||
| I-II | 66 | 38 (57.6%) | 28 (42.4%) | 0.011 |
| III | 20 | 5 (25.0%) | 15 (75.0%) | |
| T stage | ||||
| T1-T2 | 20 | 16 (80.0%) | 4 (20.0%) | 0.004 |
| T3-T4 | 66 | 27 (40.9%) | 39 (59.1%) | |
| N stage | ||||
| N0 | 40 | 26 (65.0%) | 14 (35.0%) | 0.009 |
| N1-3 | 46 | 17 (37.0%) | 29 (63.0%) | |
| TNM stage | ||||
| I-II | 46 | 31 (67.4%) | 15 (32.6%) | 0.001 |
| III | 40 | 12 (30.0%) | 28 (70.0%) | |
NOTE: The bold digit represents P value smaller than 0.05. ESCC, esophageal squamous cell carcinoma; TNM, tumor node metastasis.