Table 1. Reference range of T lymphocyte subsets in different age groups.
| parameters | All | Young | Middle-aged | Elder | p Value | |
|---|---|---|---|---|---|---|
| N=1068 | N=781 | N=246 | N=41 | |||
| Age (years) | Mean ±SD | 40.5±10.04 | 35.4±4.61 | 50.9±4.50 | 71.6±4.53 | - |
| Range | (19-80) | (19-44) | (45-64) | (65-80) | ||
| Sex | Male : Female | 731:337 | 564:217 | 134:112 | 33:8 | 0.000 |
| Lymphocyte counts | Mean ±SD | 2086 ±547 | 2106±535 | 2046±587 | 1946±505 | 0.042 |
| (cells/ul) | 95%CI | 2053-2119 | 2068-2143 | 1972-2119 | 2053-2119 | |
| CD19+ B counts | Mean ±SD | 216 ±99 | 218±97 | 213±106 | 198±112 | 0.383 |
| (cells/ul) | 95%CI | 210-222 | 211-225 | 200-226 | 163-233 | |
| CD19+ B percentage (%) | Mean ±SD | 10.40 ±3.73 | 10.38±3.56 | 10.49±4.02 | 10.17±5.00 | 0.863 |
| 95%CI | 10.18-10.63 | 10.14-10.64 | 9.9810.99 | 8.59-11.75 | ||
| CD16CD56+ NK counts | Mean ±SD | 403 ±220 | 407±215 | 376±214 | 477±305 | 0.012 |
| (cells/ul) | 95%CI | 389-416 | 392-422 | 349-403 | 381-574 | |
| CD16CD56+ NK percentage | Mean ±SD | 19.19 ±8.52 | 19.19±8.10 | 18.38±8.73 | 24.11±12.62 | 0.000 |
| (%) | 95%CI | 18.68-19.70 | 18.62-19.75 | 17.29-19.48 | 20.13-28.09 | |
| CD3+ T counts | Mean SD | 1387 ±414 | 1403±402 | 1368±449 | 1198±399 | 0.006 |
| (cells/ul) | 95%CI | 1362-1412 | 1375-1431 | 1312-1424 | 1071-1323 | |
| CD3+ T percentage | Mean ±SD | 66.44 ±8.58 | 66.62±8.17 | 66.67±8.96 | 61.73±12.12 | 0.002 |
| (%) | 95%CI | 65.93-66.96 | 66.05-67.19 | 65.55-67.80 | 57.91-65.56 | |
| CD3+CD4+T counts | Mean ±SD | 694 ±202 | 690±227 | 708±241 | 699±281 | 0.565 |
| (cells/ul) | 95%CI | 680-708 | 674-706 | 677-738 | 610-787 | |
| CD3+CD4+/CD3+ | Mean ±SD | 33.48 ±7.33 | 32.91±6.95 | 34.89±7.80 | 35.81±9.80 | 0.000 |
| (%) | 95%CI | 33.04-33.92 | 32.43-33.40 | 33.91-35.87 | 32.72-38.90 | |
| CD3+CD8+T counts | Mean ±SD | 589 ±244 | 605±234 | 561±269 | 448±235 | 0.000 |
| (cells/ul) | 95%CI | 574-604 | 589-621 | 528-595 | 374-522 | |
| CD3+CD8+/CD3+ | Mean ±SD | 27.96 ±7.67 | 28.52±7.27 | 26.97±8.12 | 23.09±9.91 | 0.000 |
| (%) | 95%CI | 27.50-28.42 | 28.01-29.03 | 25.96-27.99 | 19.96-26.21 | |
| CD4+CD45RA- | Mean ±SD | 430 ±156 | 419±147 | 459±168 | 472±212 | 0.000 |
| (cells/ul) | 95%CI | 421-440 | 408-429 | 438-480 | 406±539 | |
| CD4+CD45RA-/CD4+ | Mean ±SD | 62.81 ±11.94 | 61.52±11.17 | 65.282±12.72 | 69.28±15.77 | 0.000 |
| (%) | 95%CI | 62.09-63.52 | 60.73-62.30 | 64.23-67.42 | 64.30-7.25 | |
| CD4+CD45RA+ | Mean ±SD | 264 ±138 | 271±133 | 249±147 | 226±165 | 0.000 |
| (cells/ul) | 95%CI | 256-272 | 262-280 | 230-267 | 174-278 | |
| CD4+CD45RA+/CD4+ | Mean ±SD | 37.19 ±11.94 | 38.48±11.17 | 34.18±12.72 | 30.73±15.78 | 0.017 |
| (%) | 95%CI | 36.48-37.91 | 37.70-39.27 | 32.58-35.77 | 25.74-35.71 | |
| CD4+CD45RA+CD62L+ | Mean ±SD | 240 ±129 | 247±125 | 221±132 | 206±160 | 0.004 |
| (cells/ul) | 95%CI | 232-247 | 239-256 | 204-237 | 156-256 | |
| CD4+CD45RA+CD62L+/CD4+ | Mean ±SD | 33.87±11.80 | 35.24±11.16 | 30.55±12.16 | 27.82±15.41 | 0.000 |
| (%) | 95%CI | 33.17-34.58 | 34.45-36.02 | 29.03-32.08 | 22.95-32.68 | |
| CD4+CD28+ | Mean ±SD | 617 ±210 | 619±206 | 616±212 | 597±271 | 0.816 |
| (cells/ul) | 95%CI | 604-630 | 604-633 | 589-642 | 512-683 | |
| CD4+CD28+/CD4+ | Mean ±SD | 89.18 ±8.44 | 89.88±7.47 | 87.56±10.01 | 85.59±12.52 | 0.000 |
| (%) | 95%CI | 88.68-89.69 | 89.36-90.41 | 86.30-88.82 | 81.64-89.54 | |
| CD8+CD28+ | Mean ±SD | 329 ±132 | 348±129 | 290±121 | 191±115 | 0.000 |
| (cells/ul) | 95%CI | 321-337 | 339-357 | 274-305 | 155-228 | |
| CD8+CD28+/CD8+ | Mean ±SD | 57.71 ±14.17 | 59.41±13.38 | 54.76±14.86 | 43.16±13.50 | 0.000 |
| (%) | 95%CI | 56.86-58.56 | 58.47-60.35 | 52.89-56.62 | 38.90-47.42 | |
| CD8+HLA-DR+ | Mean ±SD | 135 ±98 | 130±97 | 148±102 | 145±92 | 0.038 |
| (cells/ul) | 95%CI | 129-141 | 124-137 | 135-161 | 116-174 | |
| CD8+HLA-DR+/CD8+ | Mean ±SD | 22.38 ±11.08 | 20.78±10.55 | 25.77±11.18 | 32.59±10.34 | 0.000 |
| (%) | 95%CI | 21.72-23.05 | 20.04-21.52 | 24.37-27.18 | 29.33-35.85 | |
| CD8+CD38+ | Mean ±SD | 184 ±111 | 202±112 | 149±92 | 57±49 | 0.000 |
| (cells/ul) | 95%CI | 178-191 | 194-210 | 138-161 | 42-73 | |
| CD8+CD38+/CD8+ | Mean ±SD | 31.91 ±14.49 | 34.05±13.53 | 28.25±15.35 | 13.02±6.75 | 0.000 |
| (%) | 95%CI | 31.04-32.78 | 33.10-35.00 | 26.32-30.18 | 10.89-15.15 | |
| CD4+/CD8+ | Mean ±SD | 1.32 ±0.59 | 1.25±0.48 | 1.45±0.69 | 1.91±1.19 | 0.000 |
| (%) | 95%CI | 1.29-1.36 | 1.22-1.29 | 1.37-1.54 | 1.54-2.29 | |