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. 2016 Jul;358(1):125–137. doi: 10.1124/jpet.116.232249

Fig. 2.

Fig. 2.

Altered levels of brain Aβ peptides in rats given single doses of BMS-932481. Rats were given intravenous doses of BMS-932481 at 1, 5, and 10 mg/kg, or vehicle alone. After dosing, groups (n = 4) of rats were euthanized at intervals between 10 minutes and 24 hours. Plasma, brain, and CSF samples were taken. Brain Aβ1-42 (A), brain Aβ1-40 (B), brain Aβ1-38 (C), brain Aβ1-37 (D), brain Aβ1-x (E), and the sum of brain Aβ1-42, Aβ1-40, Aβ1-38, and Aβ1-37 (F). (G) Stack chart showing amounts of Aβ1-42, Aβ1-40, Aβ1-38, and Aβ1-37 in brain and CSF of vehicle- and BMS-932481–dosed rats 7 hours after dosing. (H) Concentrations of BMS-932481 in blood plasma. Error bars indicate standard error. The concentrations of CSF Aβ1-42, Aβ1-40, Aβ1-38, Aβ1-37, and Aβ1-x in the same rats are shown in Supplemental Fig. 3. The significance of treatment effects was analyzed by analysis of variance (Supplemental Tables 1 and 2).