Fig. 5.
Altered levels of CSF Aβ peptides in monkeys given single doses of BMS-986133. Monkeys surgically fitted with a cannula in the lumbar spinal cord were given intravenous doses of BMS-932481 at 5 and 15 mg/kg, or vehicle alone, in a crossover study design (total of four monkeys). Plasma and CSF samples were taken predose and at intervals after dosing up to 72 hours. CSF Aβ1-42 (A), CSF Aβ1-40 (B), CSF Aβ1-38 (C), CSF Aβ1-37 (D), CSF Aβ1-x (E), and the sum of Aβ1-42, Aβ1-40, Aβ1-38, and Aβ1-37 (F). (G) Concentrations of BMS-932481 in blood plasma. (H) Scatter plot for CSF Aβ1-42 and CSF Aβ1-40 from all individual samples (total of 108 samples). Linear regression showed a best fit of y = 0.86*x + 15, r2 = 0.97, P < 0.0001. Error bars indicate standard error. The significance of treatment effects was analyzed by analysis of variance (Supplemental Table 4).