TABLE 6.
ED50 values for σR ligands in decreasing rates of responding maintained by injections of DTG (1.0 mg/kg per injection), PRE-084 (0.32 mg/kg per injection), or (+)-pentazocine (0.32 mg/kg per injection) or food presentation
ED50 values are presented with 95% confidence limits. Response rates were calculated as percentage of control response rates (sessions before drug tests), which averaged 0.311 ± 0.080 (n = 12), 0.307 ± 0.063 (n = 18), 0.272 ± 0.062 (n = 18), and 0.557 ± 0.053 (n = 19) responses per second, respectively, for DTG-, PRE-084-, (+)-pentazocine-, and food-maintained responding. The data were shown in Fig. 9.
| Compound | DTG | PRE-084 | (+)-Pentazocine | Food |
|---|---|---|---|---|
| μmol/kg | ||||
| BD 1063a | 8.52 (7.11–10.2) | 10.8 (8.99–13.2) | 11.2 (8.60–15.1) | 43.3 (15.1–10,400) |
| AZ 66 | 0.664 (0.574–0.767) | 0.700 (0.637–0.771) | 0.562 (0.503–0.627) | Approximately 108 |
| CM 304 | 2.56 (2.20–2.97) | 2.21 (2.09–2.34) | 2.91 (2.34–3.41) | >85.9 |
| SN 79 | 2.68 (1.92–4.02) | 33.3 (31.9–35.0) | 38.1 (34.2–45.4) | >66.1 |
| SN 167 | 2.03 (1.46–2.82) | >34.1 | >34.1 | 44.5 (34.0–182) |
| CM 353 | 0.498 (0.449–0.549) | >19.5 | >19.5 | 32.4 (20.3–77.1) |
| CM 398 | 0.623 (0.495–0.771) | 7.05 × 103 (389–9.71 × 107) | >7.41 | 24.8 (13.5–124) |
| (±)-SM 21 | 13.2 (12.1–14.5) | >70.5 | >70.5 | 33.4 (6.22–58.5) |
a
The values for food, DTG, and PRE-084 were calculated with data from Hiranita et al. (2011).