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. 2016 Jul;358(1):61–70. doi: 10.1124/jpet.116.233239

Fig. 5.

Fig. 5.

Inhibition of Hcys-induced NLRP3 inflammasome formation by PGE2-EA in podocytes. Podocytes were cultured for 24 hours with Hcys (40 μM) in the absence or presence of PGE2-EA (10 μM) or AEA (10 μM). (A) Images showing colocalization of NLRP3 (Alexa 488, green color) with ASC (Alexa 555, red color) in podocytes and summarized data showing the fold changes in Pearson correlation coefficient for the colocalization of NLRP3 with ASC (n = 6). (B) Images showing colocalization of Nlrp3 (Alexa 488, green color) with caspase-1 (Casp; Alexa 555, red color) in podocytes and summarized data showing the fold changes in correlation coefficient for the colocalization of NLRP3 with Casp (n = 6). *p < 0.05 versus Control #p < 0.05 versus corresponded Hcys group. PE2, prostamide E2.