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. 2016 Jul;44(7):1116–1122. doi: 10.1124/dmd.115.068676

Fig. 1.

Fig. 1.

Concentration-time data for the patients included in the analysis represented as topotecan lactone concentrations (ng/ml) versus time (hour). Patients with wild-type rs4148157 and variant rs4148157 are represented by gray circles and black open circles, respectively. The dashed line at 1 ng/ml represents the lower limit of quantitation for the assay.