TABLE 3.
Final population model estimates
| Parameter | Mean Parameter Estimate | S.E. |
|---|---|---|
| Ka (1/h; wild-type rs4148157) | 0.61 | 0.11 |
| θ1 | 1.06 | 0.25 |
| Ka (1/h; variant rs4148157) | 1.76 | 0.49 |
| V/F (l) | 40.2 | 7.0 |
| θ2 | 0.78 | 0.48 |
| CL/F (l/h) | 40.0 | 2.9 |
| θ3 | 1.25 | 0.39 |
| ω -BSV | ||
| Ka | 0.517 | 0.12 |
| V/F | 0.338 | 0.17 |
| CL/F | 0.465 | 0.11 |
| σ -RUV | ||
| Additive (ng/ml) | 0.592 | 0.44 |
BSV, between-subject variability; RUV, residual unexplained variability; θ1, estimated coefficient of the effect of ABCG2 rs4148157 G>A heterozygotes and homozygotes on the absorption rate constant; θ2, estimated exponent of the effect of the BSA on apparent volume of distribution; θ3, estimated exponent of the effect of the BSA on apparent clearance.