TABLE 2.
Relative OATP1B protein expression in different age groups investigated in this study
| Age Groups |
||||
|---|---|---|---|---|
| A | B | C | D | |
| Postnatal Age Range | <3 mo | 3 mo to <2 yr | 2 to <6 yr | 6–12 yr |
| N | 20 | 21 | 17 | 22 |
| Mean age (yr) | 0.128 | 0.715 | 3.73 | 9.14 |
| S.D. (yr) | 0.067 | 0.412 | 1.13 | 1.67 |
| Highly Glycosylated OATP1B3 | ||||
| Geometric Mean | 1.49**B,*C | 0.210*D | 0.320 | 0.637 |
| 25th to 75th percentile | 0.801–2.79 | 0.028–1.05 | 0.267–0.763 | 0.223–3.31 |
| Relative to Group D | 235% | 33% | 50% | 100% |
| Core-Glycosylated OATP1B3 | ||||
| Geometric Mean | 3.59**B,**C,*D | 0.495 | 0.399 | 0.710 |
| 25th to 75th percentile | 2.41–5.11 | 0.240–2.17 | 0.319–1.11 | 0.471–2.08 |
| Relative to Group D | 505% | 70% | 56% | 100% |
| Total OATP1B3 | ||||
| Geometric Mean | 5.31**B,**C,*D | 0.956 | 0.873 | 1.49 |
| 25th to 75th percentile | 3.33–7.86 | 0.412–3.37 | 0.720–2.21 | 0.671–4.95 |
| Relative to Group D | 357% | 64% | 59% | 100% |
| OAPT1B1 | ||||
| Geometric Mean | 0.0535 | 0.0445 | 0.0277 | 0.139 |
| 25th to 75th percentile | 0.0045–0.296 | 0.0107–0.196 | 0.0155–0.0947 | 0.0275–0.871 |
| Relative to Group D | 38% | 32% | 20% | 100% |
Statistically significant differences are marked with asterisks (*P ≤ 0.05 and **P < 0.01); superscript letters denote the comparison group.