Table 4.

Distribution of Allele Frequencies for Controls and Crohn’s Disease Subjects in Replication and Combined Cohorts

SNP	Controls MAF	CD MAF	Odds ratio	95% CI	P Value	Adjusted P Value
Replication Cohort
rs4810424	0.156	0.145	0.912	0.719 – 1.156	0.465
rs1884613	0.139	0.175	1.327	1.060 – 1.635	0.012*
rs1884614	0.152	0.175	1.196	0.957 – 1.472	0.121
rs6031543	0.154	0.143	0.918	0.733 – 1.150	0.453
rs2144908	0.147	0.156	1.071	0.854 – 1.344	0.551
rs6031550	0.236	0.213	0.880	0.725 – 1.067	0.191
rs6031551	0.236	0.222	0.922	0.759 – 1.121	0.409
rs6031552	0.237	0.214	0.881	0.728 – 1.067	0.188
rs3212172	0.153	0.142	0.909	0.721 – 1.146	0.425
rs1800963	0.410	0.399	0.956	0.809 – 1.129	0.596
Combined Cohorts
rs4810424	0.154	0.172	1.144	0.968 – 1.351	0.114	1.000
rs1884613	0.142	0.187	1.389	1.183 – 1.631	0.0001*	0.004**
rs1884614	0.151	0.188	1.295	1.104 – 1.520	0.001*	0.040**
rs6031543	0.152	0.145	0.945	0.796 – 1.121	0.517	1.000
rs2144908	0.148	0.179	1.260	1.070 – 1.484	0.006*	0.240
rs6031550	0.234	0.209	0.870	0.754 – 1.005	0.058	0.232
rs6031551	0.234	0.215	0.900	0.778 – 1.041	0.154	1.000
rs6031552	0.233	0.205	0.849	0.734 – 0.982	0.028	1.000
rs3212172	0.149	0.158	1.068	0.902 – 1.265	0.443	1.000
rs1800963	0.404	0.418	1.060	0.935 – 1.202	0.362	1.000

Distribution of the genotyped SNPs minor allele frequencies. Allelic association for individual SNPs was carried out using logistic regression by fitting an additive model. CI=confidence interval; MAF=minor allele frequency; CD= Crohn’s disease.

^*P <0.05.

^**The P values adjusted for rs1884613 and rs1884614 retained significance after correcting for multiple comparisons (40 tests).