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. Author manuscript; available in PMC: 2016 Jul 4.
Published in final edited form as: Nat Commun. 2012;3:1253. doi: 10.1038/ncomms2261

Figure 3. Chemical suppression of adult neurogenesis impairs behavioral discrimination of similar contexts.

Figure 3

a. Experimental design (similar contexts). Mice were pre-exposed to contexts A (triangle) and B (square). The following day they received an immediate shock in context B, and then 24 hours later freezing was assessed in contexts A and B. b. During the test, both VEH-treated (n = 11) and TMZ-treated (n = 12) mice froze more in context B vs. A (Context main effect, F1,21 = 56.83, p < .001). c. However, discrimination (freezingA – freezingB) was reduced in TMZ-treated mice (unpaired t-test, t21 = 3.54, p < .01). d. Experimental design (dissimilar contexts). Mice were pre-exposed to a rectangular context (located in a different room) and the square context. The following day they received an immediate shock in the square context, and then 24 hours later freezing was assessed in the square vs. rectangular contexts. e. During the test, both VEH-treated (n = 12) and TMZ-treated (n = 12) mice froze more in the square vs. rectangular context (Context main effect, F1,44 = 165.06, p < .001). f. Discrimination (freezingA – freezingB) was similar in TMZ-treated mice (unpaired t-test, t22 = 0.82, p > .05). In these graphs, error represents SEM, and significantly different contrasts are marked by * (where p < .05).