(A) HDM-asthma model, with female mice at least 6 weeks old, with (B) Airway resistance measurements by forced oscillation, (C) airway inflammation measured by BAL, and (D) goblet cell metaplasia measured by PAS-staining (purple). Airways with the greatest goblet cell metaplasia from each mouse were quantified in (E) to avoid bias in choosing a “representative airway” (WT, n = 5; KO, n = 6). MØ=macrophage, LY=lymphocyte, NE=neutrophil, EO=eosinophil. *p<0.05, **p<0.01, Student’s t-test. Error bars=S.E.M.