Skip to main content
. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: J Allergy Clin Immunol. 2016 Mar 2;138(1):187–199. doi: 10.1016/j.jaci.2015.11.024

Figure 1. Reduction in STAT3 confers resistance to anaphylaxis.

Figure 1

(A) Effect of C188–9 pretreatment (7 days) on body temperature changes in male C57Bl/6 mice during anaphylactic shock. Mice (n=5–6/group) were sensitized with 3 µg DNP-specific IgE and challenged 24 h later with 200 µg DNP-HSA. (B) Histamine and MCPT-1 released into circulation (90 sec) after challenging sensitized C188–9 or vehicle treated mice with Ag (n=6/group). Results are presented as boxplots with min/max range. Temperature changes during anaphylaxis induced by histamine (5 µmol) in C188–9 and vehicle treated C57BL/6 (C) or AD-HIES mice (D) (n=6/group). Temperature changes during anaphylaxis induced by PAF (0.3 mg) in C188–9 and vehicle treated mice (E). (F) Survival curve of mice after PAF treatment (n=6/group in B and n=5/group in C).