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. 2016 Jul 5;17(1):64. doi: 10.1186/s10194-016-0654-5

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — pERK1/2 in the trigeminal ganglion. a In fresh animals, pERK1/2 immunoreactivity was detected in a few nuclei of the trigeminal ganglia, including nucleoli, in fresh animals. No immunoreactivity was found in the neuronal cytoplasm. A few SGC were considered as positively stained. b In CFA animals repeated treatment with saline i.p., high-intensity pERK1/2 immunoreactivity was observed in SGCs. c Animals treated with KYNA for 7 days, diminished immunoreactivity to pERK1/2 in SGC