Table 2.
Most probable predicted epitopes interacting with different MHC class I and class II alleles from IEDB analysis tool
| Proteins used | Predicted peptides using IEDB tool | Interacting MHC-I alleles | Population coverage | Interacting MHC-II alleles | Conservancy | Allergenicity |
|---|---|---|---|---|---|---|
| FlaA | FRINTNVAA | HLA-C*03:03 HLA-C*12:03 HLA-C*14:02 HLA-B*39:01 HLA-C*07:01 HLA-C*06:02 |
51.40 % | HLA-DRB1*04:01 HLA-DRB1*13:02 HLA-DRB1*01:01 | 100 % conserved among 23 strains, 88.89 % conserved in 4 strains | Non-allergen |
| CadF | NYFEGNLDM | HLA-C*14:02 HLA-C*07:01 HLA-C*06:02 HLA-C*12:03 HLA-C*07:02 HLA-B*15:02 | 60.72 % | HLA-DRB1*04:05 | 100 % conserved among 13 strains | Non-allergen |
| MOMP | IFYTTGSRL | HLA-C*03:03 HLA-C*14:02 HLA-B*15:02 HLA-C*12:03 |
22.69 % | HLA-DRB1*07:01 HLA-DRB1*01:01 HLA-DPA1*02:01 HLA-DPB1*01:01 |
100 % conserved among 18 strains, 77.78 % conserved among 5 strains | Non-allergen |
| YKYSPKLNF | HLA-C*03:03 HLA-B*15:02 HLA-C*14:02 HLA-C*12:03 |
22.69 % | HLA-DRB1*11:01 HLA-DRB1*07:01 |
100 % conserved among 18 strains | Non-allergen | |
| PEB1A | YQDAIGLLV | HLA-A*02:06 HLA-C*12:03 HLA-C*05:01 HLA-A*02:01 HLA-C*08:02 |
53.42 % | HLA-DRB1*01:01 HLA- DRB1*07:01 | 100 % conserved among 8 strains, 33.33 % conserved among 10 strains, 22.22 % conserved in 1 strain | Non-allergen |
| PEB3 | FRNNIVAFV | HLA-C*06:02 HLA-C*12:03 HLA-C*07:01 HLA-C*05:01 |
47.63 % | HLA- DRB1*13:02 HLA- DRB1*04:04 HLA- DRB1*01:01 HLA- DRB3*01:01 |
100 % conserved among 40 strains, 88.89 % conserved in 1 strain | Non-allergen |
| Cia | LIMPVFHEL | HLA-A*02:06 HLA-A*02:01 HLA-C*15:02 HLA-C*12:03 HLA-A*68:02 | 50.86 % | HLA-DPA1*02:01 HLA-DPB1*01:01 HLA-DPA1*01:03 HLA-DPB1*02:01 |
100 % conserved among 20 strains |