Table 2.
Hemodynamic, pulmonary and clinical variables in animals with a drop in mean arterial pressure ≥10 %, within 24 h from bacterial inoculum
| Group | p value | ||
|---|---|---|---|
| Control (six animals) | Treatment (five animals) | ||
| Hemodynamic variables | |||
| Heart rate (beats/min) | 66.7 ± 18.6 | 75.0 ± 22.0 | 0.031 |
| Central venous pressure (mm Hg) | 7.7 ± 3.8 | 7.9 ± 2.7 | 0.653 |
| Mean arterial pressure (mm Hg) | 77.6 ± 8.3 | 77.9 ± 11.5 | 0.814 |
| Mean pulmonary arterial pressure (mm Hg) | 20.8 ± 4.7 | 21.5 ± 4.7 | 0.388 |
| Cardiac output (L/min) | 3.3 ± 1.1 | 3.6 ± 1.2 | 0.245 |
| Systemic vascular resistance (dyne/s/cm5) | 1837.2 ± 593.5 | 1703.4 ± 567.9 | 0.252 |
| Pulmonary vascular resistance (dyne/s/cm5) | 299.9 ± 127.6 | 274.5 ± 113.9 | 0.159 |
| Vasopressor dependency index | 0.25 ± 0.10 | 0.30 ± 0.17 | 0.385 |
| Mixed venous saturation (%) | 61.9 ± 11.4 | 60.3 ± 0.10 | 0.164 |
| Pv-aCO2 | 8.52 ± 3.38 | 8.78 ± 3.15 | 0.678 |
| Fluid balance (mL) | −48.9 ± 445.2 | −73.5 ± 501.9 | 0.842 |
| Pulmonary variables | |||
| PaO2/FiO2 | 353.8 ± 55.3 | 340.4 ± 81.8 | 0.792 |
| PaCO2 | 40.3 ± 4.2 | 40.7 ± 4.5 | 0.598 |
| Lung elastance (cm H2O/L) | 27.7 ± 9.2 | 25.3 ± 8.2 | 0.477 |
| Pulmonary shunt (%) | 8.8 ± 4.2 | 9.2 ± 4.1 | 0.635 |
| Clinical variables | |||
| Temperature (°C) | 38.3 ± 1.2 | 39.0 ± 1.1 | <0.001 |
| White blood cells (cells/µL) | 17.9 ± 6.8 | 13.7 ± 5.0 | 0.004 |
| Neutrophils (%) | 45.6 ± 14.6 | 42.5 ± 12.9 | 0.364 |
| Lymphocytes (%) | 46.1 ± 14.8 | 50.4 ± 13.3 | 0.234 |
| Monocytes (%) | 2.5 ± 1.2 | 3.3 ± 2.8 | 0.631 |
| Hb (g/dL) | 8.6 ± 1.2 | 8.2 ± 1.5 | 0.290 |
| Platelet (cells/mm3) | 255.0 ± 61.8 | 258.2 ± 115.1 | 0.741 |
| Creatinine (mg/dL) | 0.99 ± 0.2 | 1.3 ± 1.4 | 0.154 |
Of note, only animals with a decrease in mean arterial pressure ≥10 %, within 24 h from bacterial inoculum, were included in this post hoc analysis
Italics p values indicate statistically significant differences between study groups
Hb hemoglobin, PaCO 2 arterial partial pressure of carbon dioxide, PaO 2 /FiO 2 ratio of partial pressure arterial oxygen and fraction of inspired oxygen, Pv-aCO 2 venous-to-arterial partial pressure carbon dioxide difference