Table 3.
Nausea and vomiting outcome variables (0–120 h).
| Outcome variables | 0–2 h |
24–48 h |
24–72 h |
24–96 h |
24–120 h |
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| Aprepitant | Ondansetron | Aprepitant | Ondansetron | Aprepitant | Ondansetron | Aprepitant | Ondansetron | Aprepitant | Ondansetron | |
| Number of subjects | 48 | 47 | 48 | 47 | 48 | 47 | 48 | 47 | 48 | 47 |
| PONV, n (%) | 15 (31.3) | 17 (36.2) | 13 (27) | 8 (17) | 16 (33) | 8 (17) | 16 (33) | 16 (34) | 17 (35) | 16 (34) |
| Vomiting, n (%) | 4 (8.3) | 6 (12.8) | 1 (2.1) | 4 (8.5) | 2 (4.2) | 4 (8.5) | 2 (4.2) | 4 (8.5) | 3 (6.3) | 4 (8.5) |
| Worst vomiting score, median (IQR) | 1.5 (1, 2) | 3 (3, 3) | 1 (1, 1) | 2 (2, 2.5) | 1.5 (1, 2) | 2 (2, 3) | 1.5 (1, 2) | 2.5 (2, 3) | 1 (1, 2) | 2.5 (2. 3) |
| Any nausea incidence, n (%) | 15 (31.3) | 17 (36.2) | 12 (25) | 8 (17) | 15 (31.3) | 8 (17) | 15 (31.3) | 16 (34) | 16 (33.3) | 16 (34) |
| Significant nausea incidence (A score ≥4 on the VRS), n (%) | 3 (10) | 7 (23) | 11 (22.9) | 7 (14.9) | 16 (17) | 9 (10) | 21 (15) | 15 (11) | 25 (13) | 17 (9) |
| Worst nausea score, median (IQR) | 6 (3, 5.8) | 7 (5, 10) | 6 (5, 8) | 7 (6, 7.5) | 6.5 (4.5, 8) | 7 (6, 9) | 7 (5, 8) | 6 (4, 7) | 6 (4, 8) | 7 (6, 9) |
| Rescue antiemetics, n (%) | 3 (6) | 9 (19) | 5 (10) | 3 (6) | 6 (12.5) | 3 (6) | 6 (12.5) | 7 (15) | 7 (15) | 8 (17) |
| Postoperative opioid consumption (oral morphine mg), median (IQR) | NA | NA | 41.2 (15.0, 103.5) | 46.2 (15.0, 84.0) | 45.0 (15.0, 105.0) | 38.7 (15.0, 69.0) | 45.0 (15.0, 92.5) | 40.0 (15.0, 69.0) | 40.0 (15.0, 90.0) | 38.7 (18.0, 72.0) |
VRS, verbal rating scale; IQR, interquartile range; %, percentage; 0 hour, End of Surgery (closure time).