Table 2.
Test (T)-retest (R) comparison for [18F]THK5317 DVR regional values in five patients
| Individual | Region of Interest | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Frontal cx | Temporal cx | Parietal cx | Occipital cx | Insular cx | Anterior cingulate gyrus | Posterior cingulate gyrus | Hippocampus | Putamen | Caudate nucleus | Thalamus | |
| Prodromal AD no 1 – T | 1.20 | 1.16 | 1.06 | 1.08 | 1.29 | 1.24 | 1.25 | 1.32 | 1.67 | 1.08 | 1.34 |
| Prodromal AD no 1 – R | 1.20 | 1.14 | 1.05 | 1.08 | 1.26 | 1.22 | 1.25 | 1.30 | 1.66 | 1.08 | 1.35 |
| % Difference | −0.47 | −1.81 | −0.93 | 0.18 | −2.03 | −1.16 | 0.31 | −1.26 | −0.26 | 0.41 | 1.04 |
| Prodromal AD no 2 – T | 1.13 | 1.11 | 1.10 | 1.20 | 1.22 | 1.23 | 1.21 | 1.30 | 1.46 | 0.89 | 1.27 |
| Prodromal AD no 2 – R | 1.15 | 1.13 | 1.09 | 1.16 | 1.20 | 1.26 | 1.26 | 1.37 | 1.51 | 1.05 | 1.34 |
| % Difference | 2.29 | 1.74 | −0.39 | −2.91 | −2.30 | 2.79 | 4.21 | 5.36 | 2.93 | 18.92 | 5.38 |
| Prodromal AD no 3 – T | 1.24 | 1.14 | 1.06 | 1.17 | 1.31 | 1.23 | 1.23 | 1.44 | 1.63 | 1.31 | 1.42 |
| Prodromal AD no 3 – R | 1.24 | 1.15 | 1.05 | 1.18 | 1.32 | 1.28 | 1.29 | 1.48 | 1.62 | 1.39 | 1.48 |
| % Difference | −0.20 | 0.71 | −0.59 | 0.81 | 1.17 | 3.68 | 4.80 | 3.02 | −0.70 | 5.72 | 4.43 |
| Prodromal AD no 4 – T | 1.17 | 1.08 | 1.11 | 1.10 | 1.26 | 1.25 | 1.28 | 1.33 | 1.59 | 1.00 | 1.38 |
| Prodromal AD no 4 – R | 1.19 | 1.10 | 1.11 | 1.11 | 1.29 | 1.25 | 1.25 | 1.30 | 1.63 | 0.99 | 1.38 |
| % Difference | 1.98 | 1.42 | 0.05 | 0.27 | 2.86 | 0.52 | −1.84 | −2.65 | 2.07 | −0.58 | −0.04 |
| CBD – T | 1.09 | 1.10 | 1.05 | 1.08 | 1.23 | 1.14 | 1.21 | 1.19 | 1.79 | 0.74 | 1.20 |
| CBD – R | 1.08 | 1.06 | 1.01 | 1.03 | 1.24 | 1.11 | 1.15 | 1.11 | 1.76 | 0.74 | 1.18 |
| % Difference | −1.07 | −3.45 | −3.90 | −3.98 | 0.36 | −2.29 | −5.28 | −6.75 | −1.58 | −0.70 | −1.81 |
| Mean absolute, % Difference | 1.20 | 1.83 | 1.17 | 1.63 | 1.74 | 2.09 | 3.29 | 3.81 | 1.51 | 5.27 | 2.54 |
| Standard deviation | 0.91 | 1.00 | 1.56 | 1.71 | 0.98 | 1.27 | 2.12 | 2.21 | 1.07 | 7.96 | 2.27 |
| Intraclass correlation coefficient | 0.98 | 0.86 | 0.90 | 0.95 | 0.90 | 0.93 | 0.52 | 0.94 | 0.98 | 0.97 | 0.95 |
AD Alzheimer’s disease, cx cortex, CBD corticobasal degeneration, cx cortex, Prodromal AD mild cognitive impairment with [11C]PIB uptake above the normal range (threshold standard uptake value ratio of 1.41); % Difference: [(R-T)/T]; Intraclass correlation coefficient: [(BIMSS−WIMSS)/(BIMSS + WIMSS)], where BIMSS = between-individuals mean sum of squares, and WIMSS = within-individual mean sum of squares. Frontal, temporal, parietal and occipital cortices were defined according to the Hammers’ probabilistic atlas [21]