Table 2.

Resistance status of several Brazilian municipalities to the pyrethroid deltamethrin and allelic frequencies of the major kdr mutations found in the country.

Year	Region	State	Municipality/strain	Generation	RR50	RR95	Slope	NaV allelic frequencies
								S	R1	R2
2010	NE	RN	Rockefeller		1.0	1.0	2.96
			Caicó	F2	6.0	13.1	2.51	0.917	0.067	0.017
2011	N	RR	Rockefeller		1.0	1.0	4.55
			Pacaraima	F2	33.2	60.3	2.65	0.000	0.600	0.400
		PA	Castanhal	F2	9.9	14.9	3.05	0.667	0.300	0.033
			Marabá	F2	47.4	70.7	3.07	0.690	0.310	0.000
	SE	ES	Cachoeiro de Itapemirim	F1	49.0	78.6∗	2.16	0.103	0.224	0.672
	CW	GO	Campos Belos	F2	25.3	52.3	2.43	0.310	0.086	0.603
			Goiânia	F2	47.6	46.5	4.68
			Rio Verde	F2	32.5	56.2	2.74	0.241	0.207	0.552
			São Simão	F2	30.4	51.6	2.78	0.083	0.383	0.533
			Uruaçu	F2	38.6	51.6	3.37	0.450	0.117	0.433
2012	CW	GO	Aparecida de Goiânia	F1	33.0	57.2	2.74	0.207	0.362	0.463
			São Miguel do Araguaia	F1	39.6	49.4	3.59	0.414	0.293	0.293

RR₅₀ and RR₉₅: resistance ratios; profiles corresponding to RR₉₅ above 3.0 (bold font numbers) were classified as resistant.

^∗RR₈₀ is informed. See Table S3 for additional details.

Kdr allelic frequencies S, R1, and R2 refer to the positions 1016 and 1534 of the gene coding for the voltage gated sodium channel (Na_V) as follows: S (susceptible) = 1016 Val⁺/1534 Phe⁺; R1 (single mutant) = 1016 Val⁺/1534 Cys^kdr; and R2 (double mutant) = 1016 Ile^kdr/1534 Cys^kdr. Kdr data have been originally published by Linss et al. 2014 [20].