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. 2016 Jun 21;2016:1363902. doi: 10.1155/2016/1363902

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Copyright © 2016 Hongyu Qiao et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The effects of pretreatment with VEGF, IGF-1, and bFGF on hypoxia-induced apoptosis of bone marrow-derived mesenchymal stromal cells (BMSCs). (a) Apoptosis analysis of BMSCs by flow cytometry; when exposed to hypoxia, BMSCs treated with IGF-1 and bFGF underwent less apoptosis compared with control (10.2 ± 1.4% and 10.7 ± 2.5% versus 26.1 ± 3.4%; P < 0.05; n = 6 in each group), while the apoptosis rate of VEGF was 20.7 ± 1.9%. (b) Apoptosis analysis of BMSCs by TUNEL assay; BMSCs with bFGF and IGF-1 showed a lower calculated apoptotic rate (17.6 ± 3.5% and 19.2 ± 6.7% versus 36.0 ± 3.7%, P < 0.05), while VEGF was 28.3 ± 3.3%; ^∗ P < 0.05 versus control; n = 6 in each group. Bar scale = 80 μm.