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. 2016 Jul 4;7:12082. doi: 10.1038/ncomms12082

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(a) Brain sections of 4-month-old female (n=5) APP^swe;PS1ΔE9 mice were detected by antibodies specific to Aβ (6E10). Only a few can be detected in the female APP^swe;PS1ΔE9 mice at 4 months of age. (b) Brain sections of 6-month-old female (n=6) and male (n=4) APP^swe;PS1ΔE9 mice were detected by antibodies specific to Aβ (6E10). Wide spread neuritic plaques are observed in female APP^swe;PS1ΔE9 mice, while only a few can be detected in the male APP^swe;PS1ΔE9 mice at 6 months of age. (c) Brain sections of 12-month-old female (n=9) and male (n=7) APP^swe;PS1ΔE9 mice were detected by antibodies specific to Aβ (6E10). Wide spread neuritic plaques are observed in both male and female APP^swe;PS1ΔE9 mice at this age.