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. 2016 Jul 4;7:12082. doi: 10.1038/ncomms12082

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(a) Gallyas-Braak silver staining of brain sections of female Tau4RΔK (n=5) and Tau4RΔK-AP mice (n=4) at 9 months of age (counterstained with fast red). Cerebral cortex (CT); hippocampus (HP); olfactory bulb (OB); striatum (STR); thalamus (TH); hypothalamus (HY); midbrain (MB); Pons; Medulla (MY), and cerebellum (CB) were shown, respectively. While only sparse tau tangle was detected in frontal area of the Tau4RΔK mice, wide spread tau tangle and thread were observed in Tau4RΔK-AP mice, including brain stem. (Scale bar, 25 μm). (b) Gallyas-Braak silver staining of brain sections of female Tau4RΔK (n=4) and Tau4RΔK-AP mice (n=3) at 12 months of age (counterstained with fast red). Cerebral cortex (CT); hippocampus (HP); olfactory bulb (OB); striatum (STR); thalamus (TH); hypothalamus (HY); midbrain (MB); Pons; Medulla (MY), and cerebellum (CB) were shown, respectively. Note more tau tangles were detected in different brain regions of Tau4RΔK-AP mice as compare with that of Tau4RΔK mice. (Scale bar, 25 μm). (c) Semiquantificative score of tau tangle frequency in low power (200X) microscope field. Score was indicated as: 0, no tangle; 1, 1–5 tangles per field; 2, 6–15 tangles per field; and 3, >15 tangles per field. (Scale bar, 100 μm) (d) Score of tau tangle frequency in different brain regions of 9 months old female Tau4RΔK (n=5) and Tau4RΔK-AP (n=4) mice. Cerebral cortex (CT; T-Test, ***P=0.0006); hippocampus (HP; T-Test, ***P=0.0007); olfactory bulb (OB); striatum (STR; T-Test, ***P=0.0003); thalamus (TH; T-Test, ***P=0.0007); hypothalamus (HY; T-Test, ***P=0.0001); midbrain (MB; T-Test, ***P=0.0001); Pons(T-Test, *P=0.01); Medulla (MY; T-Test, ***P=0.0007), and cerebellum (CB) were shown. While tau tangles were only detected in frontal region in Tau4RΔK mice, widespread tau tangles were observed in whole brain of Tau4RΔK-AP mice, including brain stem. (e) Score of tau tangle frequency in different brain regions of 12 months old female Tau4RΔK (n=4) and Tau4RΔK-AP (n=3) mice. CT; HP; OB (T-Test, **P=0.002); STR; TH; HY; MB, (T-Test, *P=0.045); Pons; MY, and CB region were shown. Note more frequent tau tangles detected in different regions of Tau4RΔK-AP mice compared with that of Tau4RΔK mice, especially in olfactory bulb and brain stem.