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. 2016 Jul 4;7:12082. doi: 10.1038/ncomms12082

Figure 9. Acceleration of onset of tau pathology is dependent on the Neuritic plaque.

Figure 9

(a) Brain weight of 12-month-old female nTG (n=11), AP (n=9), TTA (n=7), TTA-AP (n=7), Tau4RΔK (n=5) and Tau4RΔK-AP (n=4) mice. The brain weight of Tau4RΔK-AP mice is 25% smaller than that of the Tau4RΔK mice at 12 month of age. (one-way analysis of variance, **P=0.002). (b) Brain weight of 12 month-old male nTG (n=11), AP (n=6), TTA (n=6), TTA-AP (n=7), Tau4RΔK (n=5) and Tau4RΔK-AP (n=5) mice. No significant difference in brain weight is detected between the male Tau4RΔK-AP and Tau4RΔK mice at 12 month of age. (c) CV staining of brain sections of 11-month-old male TTA-AP, Tau4RΔK and Tau4RΔK-AP mice brains (upper panels; scale bar, 1,000 μm; and hippocampi, lower panels; scale bar, 200 μm). (d) Neuronal cell count of CA1, and CA2&3 region from 11 months old male Tau4RΔK (n=6) and Tau4RΔK-AP (n=4) mice. No significant difference was observed between the two mouse lines. (e) Immunostaining of brain sections of 11-month-old male TTA-AP (n=5), Tau4RΔK (n=5) and Tau4RΔK-AP mice (n=4) with antibodies (6E10) specific to human Aβ. Scale bars, 200 μm. (f) Immunostaining of brain sections of 11 month-old male TTA-AP (n=5), Tau4RΔK (n=5), and Tau4RΔK-AP (n=4) mice using tau-pS422. Scale bar, 100 μm. (g) Immunostaining of brain sections of 11-month-old TTA-AP (n=5), Tau4RΔK (n=5) and Tau4RΔK-AP (n=4) mice with antibodies specific to GFAP. Scale bars, 200 μm.