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. 2016 Jul 5;10:143. doi: 10.3389/fnbeh.2016.00143

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Copyright © 2016 Flôres, Bettilyon, Jia and Yamazaki.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Prior wheel-running experience combined with a locked wheel enhances FAA. Mice were first exposed to running wheels in 18L:6D (green LEDs). Restricted feeding was initiated in either free-wheel (A–C; n = 3) or locked-wheel (D–F; n = 2) conditions. During restricted feeding, chow was manually placed and removed from the food hopper and cage bottom. In (B), FAA was quantified (AUC of the last 7 days of data) for each mouse (unique symbols connected by lines) in successive free-wheel, locked-wheel, free-wheel, and no-wheel conditions. In (E), FAA was quantified (AUC of the last 7 days of data) for each mouse (unique symbols connected by lines) in successive locked-wheel, free-wheel, locked-wheel, no-wheel conditions. Twenty-four hour group average activity profiles (C,F; dotted vertical lines indicate the time of food availability) show the mean (solid line) and standard deviation (C) or range (F) with light colored areas. Time 0 is lights on. Cage dimensions: no-wheel: 28.5 × 16.5 × 13.0 cm; with-wheel (locked and free): 29.5 × 11.5 × 12.0 cm with an 11.0 cm diameter running wheel. All individual actograms and activity profiles are shown in the Supplementary Figures 8–10.