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. 2016 Jul 4;214(1):13–24. doi: 10.1083/jcb.201605005

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© 2016 Chen and Mellone

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Figure 3. — Possible mechanisms for the formation of CENP-A nucleosomes. (A) CENP-A is deposited in its tetrameric (CENP-A-H4)₂ form onto DNA. The CENP-A octamer might form via the eviction of the placeholder (H3.1/H3.3-H4)₂ tetramers, within intact nucleosomes containing old H2A-H2B dimers. (B) Alternatively, preexisting H3.1/H3.3-containing nucleosomes could be entirely disassembled from DNA, with new (CENP-A-H4)₂ tetramers deposited, followed by the assembly of H2A-H2B dimers from a pool of old and new ones.