Table 3.

Accuracy, sensitivity, and specificity of the prediction of clinical P-gp interactions with IC₅₀ values generated from rhodamine 123 accumulation or digoxin bidirectional transport [41] assays, according to FDA criteria ¹.

Performance Metrics	Prediction from Rhodamine 123 Accumulation Assay	Prediction from Digoxin Transport Assay
Accuracy (%) 2	65.4	76.9
Sensitivity (%) 2	80.0	95.0
Specificity (%) 2	16.7	16.7

¹ FDA criteria: [I₁]/IC₅₀ > 0.1 and/or [I₂]/IC₅₀ > 10; ² values were generated from the predictions of clinical P-gp interaction for the 26 clinical DDI studies summarized in Table 2 according to FDA criteria.