. 2016 May 20;8(2):17. doi: 10.3390/pharmaceutics8020017

Table 1.

List of publications on the stabilization of drug nanosuspensions produced via wet media milling between 2006 and 2015.

References (Year)	Drug	Drug Concentration (%) ^a	Stabilizer(s) ^b	Stabilizer Concentration (%) ^a	Reported Smallest Median or Mean Particle Size after Milling (nm)
Bitterlich et al. (2015) [73]	Naproxen	5	Poloxamer-188, PVP-K 30, PVA-Mowiol 3-85, Mowiol 4-88, PVP-VA64, HPC-LF, Polysorbate-80, TPGS, SDS, HPMC	0.1–15	~150
Dong et al. (2015) [74]	SNX-2112	1	Poloxamer-188, Polysorbate-80	0.01–1	203
Kumar et al. (2015) [75]	Danazol	1	PVP-K 30, 40, PVA, HPMC-E3, E5, E15, Methocel-A15, SDS, TPGS, Poloxamer-188, 407, Dowfax-2A1, HPC	0.2	168
Afolabi et al. (2014) [45]	Griseofulvin	5–30 ^c	HPC-SL	2.5	132
Afolabi et al. (2014) [45]	Griseofulvin	5–30 ^c	SDS	0.5	132
Bhakay et al. (2014) [76]	Griseofulvin, Azodicarbonamide	10 ^c	HPC-SL, SDS	0–2.5	160
Bitterlich et al. (2014) [59]	Cinnarizine, Fenofibrate	10	DOSS	0.25	276
			SDS	0.1
			Poloxamer-188, PVP-K30, PVP-VA64, PVA-Mowiol 3–85, Polysorbate-80, HPMC, Vit-E TPGS	2.5
Komasaka et al. (2014) [77]	Cilostazol, Curucumin, Furosemide, Naproxen, Phenytoin, Nifedipine, Danazol, Spironolactone, Cinnarizine, Piroxicam, Indomethacin	10, 20	HPMC of different molecular weight, TC-5E, MC-400, Metolose, PVP-K17, Polysorbate-80, SDS, Cremophor-RH40, Poloxamer-188, Vit-E TPGS	0.5	~120
Leng et al. (2014) [78]	Paliperidone palmitate	15	Polysorbate-80	NM ^f	492 (±8)
Mahesh et al. (2014) [79]	Glipizide	1.6	SDS, Poloxamer-188, 407, Polysorbate-80	2.5–7.5 ^d	NM ^f
Mahesh et al. (2014) [79]	Glipizide	1.6	PVP-K30, HPMC	2.5–5 ^d	NM ^f
Shah et al. (2014) [80]	Glibenclamide	0.5	PVP-S630 D, Poloxamer-188, Polysorbate-80, HPMC, HPC, HEC, SDS	0.25	329
Sarnes et al. (2014) [81]	Itraconazole	15	Poloxamer-407	9–12	315 (±5)
Yuminoki et al. (2014) [82]	Griseofulvin, Hydrochlorothiazide, Tolbutamide, Acyclovir, Indomethacin, Diprydamole, Naproxen, Piroxicam, Phenytoin	1–20	HPC, PVP, POVA, PVA	1–10	120 (±2)
Bhakay et al. (2013) [58]	Griseofulvin, Phenylbutazone	10 ^c	HPC-SL, SDS	0–2.5	145
Bhakay et al. (2013) [58]	Griseofulvin, Phenylbutazone	10 ^c	Mannitol	10	145
Cerdeira et al. (2013) [83]	Miconazole, Itraconazole	5–20	SDS	0–0.2	136
			HPC-LF	1.25–5
			HPMC-E15, Poloxamer-188, 407	5
George and Ghosh (2013) [84]	Naproxen, compound A, B, C, D and E from Novartis	5	Vit-E TPGS, Poloxamer-407, SDS, DOSS	1	<500
George and Ghosh (2013) [84]	Naproxen, compound A, B, C, D and E from Novartis	5	HPMC	2.5	<500
Knieke et al. (2013) [64]	Fenofibrate	2.5	HPMC-E3	5–50 ^e	151
Knieke et al. (2013) [64]	Fenofibrate	2.5	SDS	5–20 ^e	151
Monteiro et al. (2013) [85]	Griseofulvin, Naproxen	10 ^c	HPC-SL	2.5	138
Monteiro et al. (2013) [85]	Griseofulvin, Naproxen	10 ^c	SDS	0.0825, 0.5	138
Niwa and Danjo (2013) [86]	Phenytoin	8	PVP-K30	0.25–16	168
Niwa and Danjo (2013) [86]	Phenytoin	8	SDS	0.1	168
Ghosh et al. (2012) [47]	NVS-102	2, 5	HPMC	1	277
Ghosh et al. (2012) [47]	NVS-102	2, 5	Vit-E TPGS	0.5–5	277
Tanaka et al. (2012) [6]	Probucol	1	Gelucire-44/14, Gelucire-50/13, Vit-E TPGS, Poloxamer-188, 338	1	77
Sievens-Figueroa et al. (2012) [36]	Naproxen, Fenofibrate, Griseofulvin	10^c	HPMC-E15LV	2.5 ^c	144
Sievens-Figueroa et al. (2012) [36]	Naproxen, Fenofibrate, Griseofulvin	10^c	SDS	0.075, 0.5^c	144
Ali et al. (2011) [87]	Hydrocortisone	2	PVP, Polysorbate-80	0.2	300
Ali et al. (2011) [87]	Hydrocortisone	2	HPMC	0.5	300
Bhakay et al. (2011) [65]	Itraconazole, Fenofibrate, Griseofulvin, Ibuprofen, Azodicarbonamide, Sulfamethoxazole	2^c	SA, SDS, HPMC, Polysorbate-80	0.1	740
Bhakay et al. (2011) [65]		2^c	HPMC-E15 LV	0.2	740
Cerdeira et al. (2011) [46]	Miconazole, Itraconazole, Etravirine	20	HPC-LF	5	129
Cerdeira et al. (2011) [46]	Miconazole, Itraconazole, Etravirine	20	SDS	0–0.2	129
Chin et al. (2011) [62]	Carbofuran	40.6, 44	Atlox-4913	4–7	29
			PVP-K30	1–3
			Miglyol-812	1–3
Ghosh et al. (2011) [88]	Compound NVS-102	5	Vit-E TPGS	3, 5	230.2
			SDS, HPMC, PVP-K30	1
			Poloxamer-188, 407	2
Liu et al. (2011) [89]	Indomethacin, Itraconazole	40	Polysorbate-80, PEG-6000, Poloxamer-188, 407	10–80 ^e	345
Cerdeira et al. (2010) [57]	Miconazole	5–25	HPC-LF	1.25–6.25	140
			HPC-EF, PVP-30, Poloxamer-188, HPMC-E15	1.25, 2.5
			SDS	0.0125, 0.05, 0.2
			DOSS (SD)	0.1, 5
			BKC	0.1
Juhnke et al. (2010) [63]	Naproxen	2	HPC-LF	0.5	151
Juhnke et al. (2010) [63]	Compounds A and B, from Novartis	2	HPC-LF	0.5	151
Patel et al. (2010) [90]	Famotidine	0.4	HPMC-K15M, PVP-K30, Polysorbate-80, Poloxamer-188, 407	0.4, 0.8	244.6
Baert et al. (2009) [91]	Rilpivirine (TMC278)	12.5	Poloxamer-338	3.125	200
Baert et al. (2009) [91]	Rilpivirine (TMC278)	12.5	Vit-E TPGS	3.125	200
Fakes et al. (2009) [92]	HIV-attachment inhibitor: BMS-488043	10	HPC-SL	1.25, 2.1	120
Fakes et al. (2009) [92]	HIV-attachment inhibitor: BMS-488043	10	SDS, DOSS	0.1	120
Tanaka et al. (2009) [93]	Omeprazole, Albendazole, Danazol	1	Polysorbate-80, Poloxamer-188, 407	0.05–5	102
Van Eerdenbrugh et al. (2009) [94]	Loviride, Itraconazole, Cinnarizine, Griseofulvin, Indomethacin, Mebendazole, Naproxen, Phenylbutazone, Phenytoin	20	PVP-K30, K90, PVA-PEG (K-IR), Poloxamer-188, Vit-E TPGS, PVA, Polysorbate-80	10–100	>1000
Van Eerdenbrugh et al. (2009) [94]		20	HPMC-E15, HEC, HPC, MC, NaCMC, NaAlg	1–10	>1000
Ain-Ai and Gupta (2008) [95]	Naproxen	10, 30	HPC	1–4	417
Ain-Ai and Gupta (2008) [95]	Naproxen	10, 30	AH	0–1.2	417
Choi et al. (2008) [96]	Itraconazole	8	HPC of different molecular weights	1.33	110
Deng et al. (2008) [97]	Compound A	15	Plasdone S-630	3.5, 4.1	82
Deng et al. (2008) [97]	Compound A	15	SD	0.25, 0.295	82
Lee et al. (2008) [98]	Ibuprofen, Glimepiride, Digitoxin, Naproxen, Biphenyl dimethyl dicarboxylate, Paclitaxel, Lipoic acid, Predinisolone acetate, Nifedipin, Hydrocortihydrocortisone acetate, Itraconazole	8	HPC, PVP, PEG , Poloxamer-188, 407	1.33	119 (±37)
Lee et al. (2008) [98]		8	SDS, Benzethonium chloride	1	119 (±37)
Van Eerdenbrugh et al. (2008) [23]	Loviride, Itraconazole, Cinnarizine, Griseofulvin, Indomethacin, Mebendazole, Naproxen, Phenylbutazone, Phenytoin	20^c	Vit-E TPGS	25 ^e	156
Dai et al. (2007) [99]	Poorly water soluble compound/carrageenan complex	5	Poloxamer-407	0.75	300
			Tyloxapol, HPMC-2910, HPC-SL	1.5, 2
			PVP-K30	0.75, 2
			Plasdone-S630	1.31, 2
			DOSS	0.15
Sepassi et al.(2007) [100]	Nabumetone, Halofantrine	20	HPMC-E3LV, E4M, PVP-K12, K30, K90	0.63–6.25	650
Van Eerdenbrugh et al.(2007) [101]	Loviride	20	Polysorbate-80, Poloxamer-188	50 ^e	264 (±14)
Jinno et al. (2006) [102]	Cilostazol	0.25	HPC	16.5	220
Jinno et al. (2006) [102]	Cilostazol	0.25	DOSS	0.8	220

^a With respect to suspension, w/v or w/w; ^b Names of the stabilizers are abbreviated: AH: Arginine hydrochloride; Atlox 4913: Poly(methyl methacrylate) poly(ethylene glycol) graft copolymer; BKC: Benzalkonium chloride; DOSS (SD): Dioctyl sulfosuccinate sodium salt (sodium docusate); HEC: Hydroxyethylcellulose; HPC: Hydroxypropyl cellulose; HPMC: Hydroxypropylmethyl cellulose; MC: Methylcellulose; Miglyol 812: a 60/40 (w/w) mixture of C8 and C10 triglycerides; NaAlg: Alginic acid sodium salt; NaCMC: Carboxymethylcellulose sodium salt; PEG: Polyethylene glycol; Plasdone S-630: Copoviodone, Vinyl pyrrolidone/vinyl acetate copolymer; PVA: Polyvinyl alcohol; PVA-PEG: Polyvinyl alcohol polyethylene glycol graft copolymer; PVP: Polyvinylpyrrolidone; SDS: Sodium dodecyl sulfate; SA: Sodium alginate; Vit-E TPGS: d-alpha tocopheryl polyethylene glycol 1000 succinate; POVA: PVA copolymer with grafted poly acrylic acid and poly methyl methacrylate (PMMA) groups; ^c with respect to deionized water; ^d stabilizer:drug; ^e with respect to drug weight; ^f not mentioned.