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. 2016 Jul 5;6:29090. doi: 10.1038/srep29090

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(a) Treatment strategy used in this study. (b) Pictures of tumors and the corresponding kidney in each group (N = 2) at the end of the study. (c) Tumor weights from the last day of treatment. Data was collected with two mice per group. P-value < 0.01 (**) (Student’s t test, two-tailed) was indicated. (d) The seven-week-old TH-MYCN NB transgenic mice were treated with 20 mg/kg of dinaciclib by intraperitoneal injection once daily for two days. The mice were then sacrificed, and the tumor tissues were harvested and lysed for immunoblotting with the indicated antibodies. β-Actin was used as a loading control.