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. 2016 Jul 5;6:29302. doi: 10.1038/srep29302

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(A) Bar graph represents the levels of urine β-NAG in patients with DN in each group. (B) The concentration of urine albumin: creatinine ratio (UACR) in patients with DN in each group. (C) Levels of urine 8-OHdG in each group. (D) Correlation analysis indicated that p66Shc expression in renal tissues of DN patients and the tubular interstitial damage score were positively correlated (r = 0.762, p < 0.01). (E) The p66Shc expression levels and the kidney oxidative stress were also positively correlated (r = 0.812, p < 0.01). (F) A positive correlation was found between the expression of p66Shc and urine β-NAG level (r = 0.812, p < 0.01). Correlations were also found for the concentration of UACR (G) (r = 0.830, p < 0.01) and urine 8-OHdG levels (H) (r = 0.874, p < 0.01) and p66Shc expression. The analysis of the correlation between the expression of p66Shc in the kidneys and PBMs is shown (I) (r = 0.632, p < 0.01). Values are shown as the mean ± SD. r: correlation coefficient.