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. 2016 Jul 5;6:29095. doi: 10.1038/srep29095

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Ubiquitin proteasome pathway-related genes were constructed algorithmically using Ingenuity Pathway Analysis (IPA). Red and green in the genetic network indicate up- and down-regulated genes, respectively, in HEK293 cells treated with 1.0 μg/μl MNPs@SiO₂(RITC) compared with non-treated controls for 12 h. Data set of differentially expressed genes obtained from microarray data with >1.25-fold change is shown.