Table 2. Summary table of review authors’ ratings of risk of bias and applicability concerns for each study.

Study	Risk of bias				Applicability concerns
	Patient selection	Index test	Reference standard	Flow and timing	Patient selection	Index test	Reference standard
DISCOVER-FLOW4	⊕	⊕	⊕	⊕	⊕	⊕	⊕
DeFACTO5	⊕	⊕	⊕	⊕	⊕	⊕	⊕
NXT8	⊕	⊕	⊕	⊕	⊕	⊕	⊕
Kim et al.6	⊕	⊕	⊕	⊕	⊕	⊕	⊕
Renker et al.7	⊕	⊕	⊕	⊕	⊕	⊕	⊕
Coenen et al.12	⊕	⊕	⊕	⊕	⊕	⊕	⊕
Geer et al.13	⊕	⊕	⊕	⊕	⊕	⊕	⊕

⊕ Low Risk.

⊖ High Risk.

? Unclear Risk.