Table 4. Incidence rate, crude and adjusted HRs of ischemic stroke associated with acetylcholinesterase inhibitors use during the follow-up period in the propensity score–matched dementia cohort.
| No. of patients with ischemic stroke | Incidence rate (95% CI) | Crude |
Adjusted* |
P for trend | |||
|---|---|---|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | ||||
| Total AChEIs use duration | <0.001 | ||||||
| Nonuser (<28 cDDDs) | 646 | 235.4 (217.7–254.2) | Reference | Reference | |||
| User (28–365 cDDDs) | 227 | 195.9 (171.7–222.7) | 0.757 (0.621–0.921) | 0.006 | 0.646 (0.567–0.736) | <0.001 | |
| User (>365 cDDDs) | 174 | 132.1 (113.6–152.9) | 0.517 (0.416–0.641) | <0.001 | 0.587 (0.512–0.672) | <0.001 | |
Abbreviations: AChEIs, acetylcholinesterase inhibitors.
*Propensity score–matched time-dependent Cox proportional hazards model and further adjustment for medications in observation period.