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. 2016 Mar 24;9(2):18. doi: 10.3390/ph9020018

Figure 5.

Figure 5

PBISe inhibits the growth of spontaneous murine HCC mediated by apoptosis and regulating angiogenesis. MRI was performed to confirm the initial size of the tumor prior to the start of the PBISe treatment. PBISe (2.5 ppm as se) was administered intra peritoneal (i.p.) to the HCC mice, every alternate day for about 6 weeks. (A) shows the regression of the tumor size (n = 6). MRI images taken at week 1 through week 6 are shown (B). Role of PBISe on angiogenesis is demonstrated on the PBISe treated murine HCC by IHC. PBISe decreased VEGFR3, VEGF and CD34 (C). Additionally, the inhibition of pAkt, pErk and pSTAT3 is demonstrated (D).