Table 1.
Effect of ethynyl-estradiol (EE2) or citalopram (CIT) on the number (#) of counts of swimming and climbing behavior scored in the forced swim test after one or three weeks post-OVX.
| Treatment | Post-OVX Interval | # of Counts of Swimming | # of Counts of Climbing |
|---|---|---|---|
| Oil | One Week | 9.3 ± 1.4 | 9.2 ± 1.0 |
| EE2 1.25 (µg/rat) | 13.5 ± 1.6 | 9.1 ± 2.0 | |
| EE2 2.5 (µg/rat) | 19.0 ± 3.9 | 12.5 ± 1.8 | |
| EE2 5.0 (µg/rat) | 27.1 ± 4.4 **,## | 7.0 ± 2.1 | |
| SAL † | 9.3 ± 1.4 | 10.8 ± 2.6 | |
| CIT 1.25 | 10.3 ± 1.5 | 7.0 ± 1.6 | |
| CIT 2.5 | 10.7 ± 3.3 | 6.4 ± 0.7 | |
| CIT 5.0 | 12.0 ± 3.0 | 8.1 ± 1.2 | |
| CIT 10 | 17.0 ± 3.5 | 6.8 ± 1.4 | |
| OIL | Three Weeks | 11.3 ± 2.4 | 10.0 ± 1.6 |
| EE2 1.25 | 11.3 ± 2.1 | 8.1 ± 1.2 | |
| EE 2.5 | 10.3 ± 2.0 | 7.8 ± 1.6 | |
| EE2 5.0 | 9.1 ± 1.8 | 10.8 ± 2.0 | |
| SAL | 10.5 ± 1.8 | 9.7 ± 2.4 | |
| CIT 1.25 | 7.8 ± 1.8 | 9.7 ± 2.4 | |
| CIT 2.5 | 9.3 ± 2.3 | 5.6 ± 1.2 | |
| CIT 5.0 | 16.5 ± 3.9 | 5.8 ± 2.1 | |
| CIT 10 | 12.2 ± 2.0 | 11.4 ± 3.2 |
The data are shown as mean ± S.E.M of the number of counts for swimming and climbing behaviors scored in 5-sec intervals in a 5-min session of forced swimming. † SAL = saline. Holm-Sidack test; ** p < 0.001 versus the control group; ## p < 0.001 versus three weeks.