Table 3.
Effect of the combination of ethynyl-estradiol plus citalopram on the number of counts of swimming and climbing behaviors scored in the forced swim test after one or three weeks post-OVX.
| Treatment | Time Post-OVX | Swimming | Climbing |
|---|---|---|---|
| OIL/SAL | One Week | 8.3 ± 0.68 | 10.1 ± 1.5 |
| EE2 (1.25 µg/rat) | 13.5 ± 1.6 | 9.1 ± 2.0 | |
| CIT (2.5 mg/kg) | 10.7 ± 3.3 | 6.4 ± 0.7 | |
| EE2/CIT | 24.8 ± 2.5 **,## | 9.0 ± 2.6 | |
| OIL/SAL | Three Weeks | 14.2 ± 2.5 | 8.0 ± 1.8 |
| EE2 (1.25 µg/rat) | 11.3 ± 2.1 | 8.1 ± 1.2 | |
| CIT (2.5 mg/kg) | 9.3 ± 2.3 | 9.7 ± 2.4 | |
| EE2/CIT | 9.8 ± 2.6 | 7.1 ± 1.4 |
The data are presented as mean ± S.E.M of the number of counts for swimming and climbing scored in 5-sec intervals in a 5-min session of forced swimming. Holm-Sidack test ** p < 0.001 versus the control group; ## p < 0.001 versus three weeks.